Potassium Hydroxide → 4-Benzyloxybenzamide

HRID 453103노트

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HRID 453103 반응식
[CH2:1]([O:8][C:9]1[CH:16]=[CH:15][C:12]([C:13]#[N:14])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-:17].[K+]>C(O)(C)(C)C.[Cl-].[Na+].O>[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([C:13]([NH2:14])=[O:17])=[CH:15][CH:16]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 2

HCID 14797Potassium HydroxideHCID 5613714-Benzyloxybenzonitrile

생성물 1

HCID 27264314-Benzyloxybenzamide수율 101.3%

시약·촉매·용매 2

HCID 6386tert-Butanol용매HCID 57417360Sodium chloride; water용매

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온도
78 °C

실험 절차

To a solution of 4-benzyloxybenzonitrile (0.61 g, 2.91 mmol) in 15 ml of tert-butanol was added fine powder of KOH (1.22 g, 21.78 mmol) and the resulting reaction mixture was refluxed for 4 h at 78° C. After the completion of the reaction (TLC monitoring), added brine solution and extracted with ethyl acetate (3×50 ml). The combined organic layer was dried over Na2SO4, filtered and concentrated under vacuum, to get the product (0.67 g) that was used as such for the next step.

후처리

  1. customthe resulting reaction mixture
  2. customAfter the completion of the reaction (TLC monitoring)
  3. extractionextracted with ethyl acetate (3×50 ml)
  4. dry with materialThe combined organic layer was dried over Na2SO4
  5. filtrationfiltered
  6. concentrationconcentrated under vacuum

출처 및 근거

ORD 기록
ord-601a0271a430444ca570020d1a338b7c
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08492414B2

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