Hydrochloric Acid → 2-Phenyl-5-(pyrrolidin-1-ylmethyl)thiazole-4-carboxylate hydrochloride

HRID 453288노트

반응식

HRID 453288 반응식
[ClH:1].[C:2]1([C:8]2[S:9][C:10]([CH2:20][N:21]3[CH2:25][CH2:24][CH2:23][CH2:22]3)=[C:11]([C:13]([O:15]C(C)(C)C)=[O:14])[N:12]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C1COCC1>[ClH:1].[C:2]1([C:8]2[S:9][C:10]([CH2:20][N:21]3[CH2:25][CH2:24][CH2:23][CH2:22]3)=[C:11]([C:13]([OH:15])=[O:14])[N:12]=2)[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 67425601Tert-butyl 2-phenyl-5-(pyrrolidin-1-ylmethyl)thiazole-4-carboxylate

생성물 1

HCID 674258692-Phenyl-5-(pyrrolidin-1-ylmethyl)thiazole-4-carboxylate hydrochloride수율 82%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Concentrated HCl (2.8 ml, 33.9 mmol) was added to a solution of tert-butyl 2-phenyl-5-(pyrrolidin-1-ylmethyl)thiazole-4-carboxylate (2.1 g, 6.1 mmol) in THF (30 ml). The mixture was stirred at rt overnight, and concentrated in vacuo to give 2-phenyl-5-(pyrrolidin-1-ylmethyl)thiazole-4-carboxylate hydrochloride (1.5 g, 82% yield).

후처리

  1. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-dd6ed0a6c7d747779ad1d21e8251e6cb
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08492401B2

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