Ethyl 4-phenyl-1,3-thiazole-2-carboxylate → 4-Phenylthiazole-2-carboxylic acid

HRID 453299노트

반응식

HRID 453299 반응식
C([O:3][C:4]([C:6]1[S:7][CH:8]=[C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:10]=1)=[O:5])C>C1COCC1.[OH-].[Na+]>[C:11]1([C:9]2[N:10]=[C:6]([C:4]([OH:5])=[O:3])[S:7][CH:8]=2)[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

참가 물질

4

반응물 1

HCID 24730326Ethyl 4-phenyl-1,3-thiazole-2-carboxylate

생성물 1

HCID 38785394-Phenylthiazole-2-carboxylic acid

시약·촉매·용매 2

HCID 8028Tetrahydrofuran용매HCID 14798Sodium Hydroxide용매

실험 절차

Ethyl-4-phenylthiazole-2-carboxylate (300 mg) was stirred overnight in a mixture of THF (4 mL) and 1N aqueous NaOH (1 mL) for 18 hours. The THF was removed under reduced pressure and the aqueous solution was acidified with 4N HCl, extracted with CH2Cl2, dried over Na2SO4 and concentrate to obtain 4-phenylthiazole-2-carboxylic acid which was used as is in the next step.

후처리

  1. customThe THF was removed under reduced pressure
  2. extractionextracted with CH2Cl2
  3. dry with materialdried over Na2SO4
  4. concentrationconcentrate

출처 및 근거

ORD 기록
ord-ebe37f5047ed465890e100c15a560b13
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08492401B2

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