4-Phenylbutyric Acid → HCID 59369662, 화합물

HRID 45380

반응식

HRID 45380 반응식
[C:1]1([CH2:7][CH2:8][CH2:9][C:10]([OH:12])=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:13]([NH:20][C:21]([C:23]1[S:27][C:26]([NH2:28])=[N:25][C:24]=1[CH3:29])=[O:22])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[CH2:13]([NH:20][C:21]([C:23]1[S:27][C:26]([NH:28][C:10](=[O:12])[CH2:9][CH2:8][CH2:7][C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)=[N:25][C:24]=1[CH3:29])=[O:22])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

참가 물질

3

반응물 2

HCID 47754-Phenylbutyric AcidHCID 210824N-Benzyl-2-imino-4-methyl-2,3-dihydro-1,3-thiazole-5-carboximidic acid

생성물 1

HCID 59369662HCID 59369662, 화합물수율 47%

실험 절차

Following the procedure as described in Example 11, making variations only as required to use 4-phenylbutanoic acid in place of 5-phenylpentanoic acid to react with 2-amino-4-methylthiazole-5-carboxylic acid benzylamide, the title compound was obtained as a white solid in 47% yield; m.p. 45-46° C.; 1H NMR (CDCl3, 300 MHz) δ 11.13 (s, br, 1H), 7.35-7.09 (m, 10H), 6.24 (t, J=5.0 Hz, 1H), 4.59 (d, J=5.6 Hz, 2H), 2.63 (t, J=7.5 Hz, 2H), 2.52 (s, 3H), 2.41 (t, J=7.5 Hz, 2H), 2.00 (q, J=7.5 Hz, 2H); MS (ES+) m/z 397.5 (M+1).

출처 및 근거

ORD 기록
ord-3fcc7d5f6d0a4652971d6e814a187c83
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08541457B2

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