2-(7-Cyano-1H-indol-1-yl)acetic acid → 2-(7-(Aminomethyl)-1H-indol-1-yl)acetic acid

HRID 453917노트

반응식

HRID 453917 반응식
[C:1]([C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:11]=1[N:10]([CH2:12][C:13]([OH:15])=[O:14])[CH:9]=[CH:8]2)#[N:2].[H][H]>CO.[Ni]>[NH2:2][CH2:1][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:11]=1[N:10]([CH2:12][C:13]([OH:15])=[O:14])[CH:9]=[CH:8]2

참가 물질

5

반응물 2

HCID 594737242-(7-Cyano-1H-indol-1-yl)acetic acidHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 594736972-(7-(Aminomethyl)-1H-indol-1-yl)acetic acid수율 96%

시약·촉매·용매 2

HCID 935Nickel촉매HCID 887Methanol용매

실험 절차

Raney Ni (7.0 g) was added to a solution of 2-(7-cyano-1H-indol-1-yl)acetic acid (700 mg, 3.5 mmol) in MeOH (15 ml), and the mixture was hydrogenated for 6 h at RT and 60 psi hydrogen in a Parr apparatus. The reaction mixture was filtered over celite and the filtrate was concentrated under vacuum. The crude product so obtained was used directly in the following stage without being purified further. Yield: 96% (692 mg, 3.36 mmol)

후처리

  1. filtrationThe reaction mixture was filtered over celite
  2. concentrationthe filtrate was concentrated under vacuum

출처 및 근거

ORD 기록
ord-8fff7e95da214424820948a9ade5d236
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08492559B2

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