Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 454041생성일: 2026년 10월 25일
Hydrochloric Acid → 4-(2,3-Dimethylindol-5-ylamino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline hydrochloride
https://huagongshe.com/reaction/454041
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 2,3-dimethyl-1H-indol-5-amine | HCID 258688 | — |
| 반응물 | 4-Chloro-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazoline | HCID 11782230 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | 4-(2,3-Dimethylindol-5-ylamino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline hydrochloride | HCID 22030663 | 79% |
반응 단계
A suspension of 4-chloro-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline (100 mg, 0.31 mmol), (prepared as described for the starting material in Example 10), and 5-amino-2,3-dimethylindole (55 mg, 0.34 mmol) in isopropanol (6 ml) containing 5.5M hydrogen chloride in isopropanol (60 μL) was heated for 30 minutes at 70° C. After cooling, the solid was collected by filtration, washed with isopropanol, followed by ether and dried under vacuum to give 4-(2,3-dimethylindol-5-ylamino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline hydrochloride (118 mg, 74%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08492560B2 |
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| 출처 데이터셋 | uspto-grants-2013_07 |
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| ORD ID | ord-6e105cc4853b4559b5c5a6551d479e33 |
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| 출처 메모 | uspto-grants-2013_07 |
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