Ammonium formate → 4-(2,3-Dimethylindol-5-yloxy)-7-hydroxy-6-methoxyquinazoline

HRID 454092

반응식

HRID 454092 반응식
C([O:8][C:9]1[CH:18]=[C:17]2[C:12]([C:13]([O:19][C:20]3[CH:21]=[C:22]4[C:26](=[CH:27][CH:28]=3)[NH:25][C:24]([CH3:29])=[C:23]4[CH3:30])=[N:14][CH:15]=[N:16]2)=[CH:11][C:10]=1[O:31][CH3:32])C1C=CC=CC=1.C([O-])=O.[NH4+]>CN(C=O)C.[Pd]>[CH3:29][C:24]1[NH:25][C:26]2[C:22]([C:23]=1[CH3:30])=[CH:21][C:20]([O:19][C:13]1[C:12]3[C:17](=[CH:18][C:9]([OH:8])=[C:10]([O:31][CH3:32])[CH:11]=3)[N:16]=[CH:15][N:14]=1)=[CH:28][CH:27]=2

참가 물질

5

반응물 2

HCID 2723923Ammonium formateHCID 220308297-Benzyloxy-4-(2,3-dimethylindol-5-yloxy)-6-methoxyquinazoline

생성물 1

HCID 1357631184-(2,3-Dimethylindol-5-yloxy)-7-hydroxy-6-methoxyquinazoline수율 69.8%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 6228Dimethylformamide용매

실험 절차

A solution of 7-benzyloxy-4-(2,3-dimethylindol-5-yloxy)-6-methoxyquinazoline (2 g, 4.7 mmol) in DMF (120 ml) containing ammonium formate (11 gr, 174 mmol) and 10% palladium on charcoal (200 mg) was stirred for 2.5 hours at ambient temperature. The mixture was filtered, and the filtrate was evaporated under vacuum. The residue was triturated with ether and the solid was filtered, washed with water followed by ether and dried under vacuum at 50° C. to give 4-(2,3-dimethylindol-5-yloxy)-7-hydroxy-6-methoxyquinazoline (1.1 g, 69%).

후처리

  1. filtrationThe mixture was filtered
  2. customthe filtrate was evaporated under vacuum
  3. customThe residue was triturated with ether
  4. filtrationthe solid was filtered
  5. washwashed with water
  6. customdried under vacuum at 50° C.

출처 및 근거

ORD 기록
ord-7218090d733b4b65ac2cc4aa660ad0b1
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08492560B2

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