Dichloromethane → HCID 22030751, 화합물

HRID 454217노트

반응식

HRID 454217 반응식
[C:1]([CH2:4][C:5]1[C:6]([F:15])=[C:7]([F:14])[CH:8]=[CH:9][C:10]=1[N+:11]([O-:13])=[O:12])(=[O:3])[CH3:2].O.[O-2].[O-2].[O-2].O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.[Al+3].[Al+3].[CH:34](OC)(OC)[O:35]C.[CH2:41](Cl)Cl>>[F:14][C:7]1[CH:8]=[CH:9][C:10]([N+:11]([O-:13])=[O:12])=[C:5]([CH2:4][C:1]([O:35][CH3:34])([O:3][CH3:41])[CH3:2])[C:6]=1[F:15]

참가 물질

5

반응물 4

HCID 6344DichloromethaneHCID 9005Trimethyl orthoformateHCID 142688761-(2,3-Difluoro-6-nitrophenyl)propan-2-oneHCID 71586775Bentonite

생성물 1

HCID 22030751HCID 22030751, 화합물수율 88%

실험 절차

A solution of 3-acetylmethyl-1,2-difluoro-4-nitrobenzene (500 mg, 2.3 mmol) in methylene chloride (5 ml) containing montmorillonite K10 (1 g) and trimethyl orthoformate (5 ml) was stirred for 24 hours at ambient temperature. The solid was filtered, washed with methylene chloride and the filtrate was evaporated to give 1,2-difluoro-3-(2,2-dimethoxypropyl)-4-nitrobenzene (534 mg, 88%).

후처리

  1. filtrationThe solid was filtered
  2. washwashed with methylene chloride
  3. customthe filtrate was evaporated

출처 및 근거

ORD 기록
ord-1178c177a3314f07bb24ac25871386d9
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08492560B2

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