Sodium Hydroxide → 2-(Benzyloxy)-5-(oxazol-5-yl)benzoic acid

HRID 454481노트

반응식

HRID 454481 반응식
[OH-].[Na+].[CH2:3]([O:10][C:11]1[CH:20]=[CH:19][C:18]([C:21]2[O:25][CH:24]=[N:23][CH:22]=2)=[CH:17][C:12]=1[C:13]([O:15]C)=[O:14])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1>O1CCOCC1>[CH2:3]([O:10][C:11]1[CH:20]=[CH:19][C:18]([C:21]2[O:25][CH:24]=[N:23][CH:22]=2)=[CH:17][C:12]=1[C:13]([OH:15])=[O:14])[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 66990185Methyl 2-(benzyloxy)-5-(oxazol-5-yl)benzoate

생성물 1

HCID 669904842-(Benzyloxy)-5-(oxazol-5-yl)benzoic acid수율 87.6%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

A 2 mol/L aqueous solution of sodium hydroxide (4.5 mL) was added to a dioxane (5 mL) solution of the obtained methyl 2-(benzyloxy)-5-(oxazol-5-yl)benzoate (0.55 g), followed by stirring at room temperature for 2 hours and 40 minutes. The solvent was evaporated under reduced pressure, and water was added to the residue. After adjusting the pH to 4.0 with 6 mol/L hydrochloric acid, the solid substance was collected by filtration to obtain 0.46 g of 2-(benzyloxy)-5-(oxazol-5-yl)benzoic acid as a light yellow solid.

후처리

  1. customThe solvent was evaporated under reduced pressure, and water
  2. additionwas added to the residue
  3. filtrationthe solid substance was collected by filtration

출처 및 근거

ORD 기록
ord-56ae76fa954e4a91af3af4c37ee4fd94
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08492582B2

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