Sodium Hydroxide → 5-(Pyrimidin-2-yl)pyridine-3-carboxylic acid

HRID 454526노트

반응식

HRID 454526 반응식
[OH-].[Na+].[N:3]1[CH:8]=[CH:7][CH:6]=[N:5][C:4]=1[C:9]1[CH:10]=[C:11]([C:15]([O:17]C)=[O:16])[CH:12]=[N:13][CH:14]=1>O1CCOCC1.CO>[N:3]1[CH:8]=[CH:7][CH:6]=[N:5][C:4]=1[C:9]1[CH:10]=[C:11]([C:15]([OH:17])=[O:16])[CH:12]=[N:13][CH:14]=1

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 66989995Methyl 5-(pyrimidin-2-yl)pyridine-3-carboxylate

생성물 1

HCID 669912565-(Pyrimidin-2-yl)pyridine-3-carboxylic acid수율 25%

시약·촉매·용매 2

HCID 887Methanol용매HCID 312751,4-Dioxane용매

실험 절차

A 2 mol/L aqueous solution of sodium hydroxide (0.21 mL) was added to a solution mixture of the obtained methyl 5-(pyrimidin-2-yl)pyridine-3-carboxylate (30 mg) in dioxane (0.3 mL) and methanol (0.3 mL) at room temperature, followed by stirring at the same temperature for 1 hour and 30 minutes. The solvent was evaporated under reduced pressure, and water and toluene were added to the residue. The aqueous layer was separated and adjusted to a pH of 3.8 with 1 mol/L hydrochloric acid. The solid substance was collected by filtration to obtain 7.0 mg of 5-(pyrimidin-2-yl)pyridine-3-carboxylic acid as a white solid.

후처리

  1. customThe solvent was evaporated under reduced pressure, and water and toluene
  2. additionwere added to the residue
  3. customThe aqueous layer was separated
  4. filtrationThe solid substance was collected by filtration

출처 및 근거

ORD 기록
ord-73f62f057064405a985188929029d79c
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08492582B2

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