Citric Acid → 5-(Furan-3-yl)pyridine-3-carboxylic acid

HRID 454527노트

반응식

HRID 454527 반응식
[OH-].[Na+].[O:3]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([C:14]([O:16]C)=[O:15])[CH:11]=[N:12][CH:13]=2)=[CH:4]1.C(O)(=O)CC(CC(O)=O)(C(O)=O)O>CO>[O:3]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([C:14]([OH:16])=[O:15])[CH:11]=[N:12][CH:13]=2)=[CH:4]1

참가 물질

5

반응물 3

HCID 311Citric AcidHCID 14798Sodium HydroxideHCID 66989989Methyl 5-(furan-3-yl)pyridine-3-carboxylate

생성물 1

HCID 639483225-(Furan-3-yl)pyridine-3-carboxylic acid수율 65.6%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A 4 mol/L aqueous solution of sodium hydroxide (2.0 mL) was added to a methanol (10 mL) solution of methyl 5-(furan-3-yl)pyridine-3-carboxylate (0.54 g) at room temperature, followed by stirring at the same temperature for 2 hours and 50 minutes. A 10% aqueous solution of citric acid (8 mL) was added to the reaction mixture at room temperature, and the solvent was evaporated under reduced pressure. Water was added to the obtained residue, and the solid substance was collected by filtration to obtain 0.33 g of 5-(furan-3-yl)pyridine-3-carboxylic acid as a light yellow solid.

후처리

  1. customthe solvent was evaporated under reduced pressure
  2. additionWater was added to the obtained residue
  3. filtrationthe solid substance was collected by filtration

출처 및 근거

ORD 기록
ord-0f5757db9a114f4ea4c086d54b75ce06
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08492582B2

반응 노트

불러오는 중…