Sodium hydride → 2-(3-Fluoropropoxy)-5-bromopyridine

HRID 454807

반응식

[H-].[Na+].[F:3][CH2:4][CH2:5][CH2:6][OH:7].[Br:8][C:9]1[CH:10]=[CH:11][C:12](Cl)=[N:13][CH:14]=1>>[F:3][CH2:4][CH2:5][CH2:6][O:7][C:12]1[CH:11]=[CH:10][C:9]([Br:8])=[CH:14][N:13]=1

참가 물질

반응물 3

HCID 24758Sodium hydride

HCID 680423-Fluoro-1-propanol

HCID 27344145-Bromo-2-chloropyridine

생성물 1

HCID 684961512-(3-Fluoropropoxy)-5-bromopyridine수율 98.6%

실험 절차

2-(3-Fluoropropoxy)-5-bromopyridine (97c, 600 mg, 98%) was prepared in the same manner as in Preparation Example 13 using sodium hydride (94 mg, 3.90 mmol), 3-fluoropropanol (305 mg, 3.90 mmol) and 5-bromo-2-chloropyridine (96, 500 mg, 2.60 mmol).

출처 및 근거

ORD 기록: ord-8e425a4d3cdd44f08bd1c8e092a0fae1
출처 데이터셋: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08497260B2

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