Water → 5-Iodo-N,N-dimethylpyridin-2-amine

HRID 454809

반응식

HRID 454809 반응식
[CH3:1][NH:2][C:3]1[CH:8]=[CH:7][C:6]([I:9])=[CH:5][N:4]=1.[C:10](=O)([O-])[O-].[K+].[K+].IC.O>CC(N(C)C)=O>[CH3:1][N:2]([C:3]1[CH:8]=[CH:7][C:6]([I:9])=[CH:5][N:4]=1)[CH3:10]

참가 물질

6

반응물 4

HCID 962WaterHCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 11253290(5-Iodo-pyridin-2-yl)-methyl-amine

생성물 1

HCID 234385795-Iodo-N,N-dimethylpyridin-2-amine수율 57%

시약·촉매·용매 1

HCID 31374Dimethylacetamide용매

반응 조건

온도
90 °C

실험 절차

The obtained 2-(N-monomethylamino)-5-iodopyridine (99, 1.00 g, 4.27 mmol), potassium carbonate (2.95 g, 21.36 mmol) and iodomethane (145 mg, 8.546 mmol) were dissolved in dimethylacetamide (30 mL), and the reaction mixture was heated at 90° C. for 24 hours, followed by adding water. Organic compounds were extracted with ethyl acetate and evaporated after a treatment with sodium sulfate. Purification was performed by column chromatograph to give the target compound 2-(N,N-dimethylamino)-5-iodopyridine (100, 603 mg, 57%).

후처리

  1. extractionOrganic compounds were extracted with ethyl acetate
  2. customevaporated after a treatment with sodium sulfate
  3. customPurification

출처 및 근거

ORD 기록
ord-f7704ee6c4784f8ab3530aa48939cf40
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08497260B2

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