Dimethylamine methanol → HCID 46947726, 화합물

HRID 454814

반응식

Cl[C:2]1[N:7]=[C:6]([C:8]2[S:9][C:10]3[CH:16]=[C:15]([O:17][CH2:18][CH2:19][F:20])[CH:14]=[CH:13][C:11]=3[CH:12]=2)[CH:5]=[CH:4][N:3]=1.CO.[CH3:23][NH:24][CH3:25]>>[CH3:23][N:24]([C:2]1[N:7]=[C:6]([C:8]2[S:9][C:10]3[CH:16]=[C:15]([O:17][CH2:18][CH2:19][F:20])[CH:14]=[CH:13][C:11]=3[CH:12]=2)[CH:5]=[CH:4][N:3]=1)[CH3:25]

참가 물질

반응물 2

HCID 22497844Dimethylamine methanol

HCID 86646556HCID 86646556, 화합물

생성물 1

HCID 46947726HCID 46947726, 화합물수율 93.3%

실험 절차

2-[2-(N,N-Dimethylamino)pyrimidine-4-yl]-6-(2-fluoroethoxy)benzothiophene (1-36, 77 mg, 93%) was prepared in the same manner as in Example 35 as a yellow solid using 2-(2-chloropyrimidine-4-yl)-6-(2-fluoroethoxy)benzothiophene (105b, 80 mg, 0.26 mmol) obtained in Preparation Example 20 and a 2.0 M dimethylamine methanol solution (NHMe2 in MeOH, 0.26 mL, 0.52 mmol).

후처리

customobtained in Preparation Example 20

출처 및 근거

ORD 기록: ord-96170d9aa23544a8a1f48cc3111b62dc
출처 데이터셋: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08497260B2

연결된 노트

불러오는 중…