Sodium methanolate methanol → 2-(2-Methoxypyrimidine-4-yl)-6-(3-fluoropropoxy)benzothiophene

HRID 454815

반응식

HRID 454815 반응식
Cl[C:2]1[N:7]=[C:6]([C:8]2[S:9][C:10]3[CH:16]=[C:15]([O:17][CH2:18][CH2:19][CH2:20][F:21])[CH:14]=[CH:13][C:11]=3[CH:12]=2)[CH:5]=[CH:4][N:3]=1.[CH3:22][OH:23].C[O-].[Na+]>>[CH3:22][O:23][C:2]1[N:7]=[C:6]([C:8]2[S:9][C:10]3[CH:16]=[C:15]([O:17][CH2:18][CH2:19][CH2:20][F:21])[CH:14]=[CH:13][C:11]=3[CH:12]=2)[CH:5]=[CH:4][N:3]=1

참가 물질

3

반응물 2

HCID 23694274Sodium methanolate methanolHCID 866465572-(2-Chloropyrimidine-4-yl)-6-(3-fluoropropoxy)benzothiophene

생성물 1

HCID 469477272-(2-Methoxypyrimidine-4-yl)-6-(3-fluoropropoxy)benzothiophene수율 107.1%

실험 절차

2-(2-Methoxypyrimidine-4-yl)-6-(3-fluoropropoxy)benzothiophene (1-37, 75 mg, 99%) was prepared in the same manner as in Example 34 as a yellow solid using 2-(2-chloropyrimidine-4-yl)-6-(3-fluoropropoxy)benzothiophene (105c, 70 mg, 0.22 mmol) obtained in Preparation Example 21 and a 0.5 M sodium methoxide methanol solution (0.66 mL, 0.33 mmol).

후처리

  1. customobtained in Preparation Example 21

출처 및 근거

ORD 기록
ord-c8fc7ab694bd43689ca6f6e6ee919af6
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08497260B2

연결된 노트

불러오는 중…