Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Monomethylamine methanol → 2-[2-(N-monomethylamino)pyrimidine-4-yl]-6-(3-fluoropropoxy)benzothiophene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Monomethylamine methanol | HCID 57454252 | — |
| 반응물 | 2-(2-Chloropyrimidine-4-yl)-6-(3-fluoropropoxy)benzothiophene | HCID 86646557 | — |
| 생성물 | 2-[2-(N-monomethylamino)pyrimidine-4-yl]-6-(3-fluoropropoxy)benzothiophene | HCID 46947728 | 81% |
반응 단계
2-[2-(N-Monomethylamino)pyrimidine-4-yl]-6-(3-fluoropropoxy)benzothiophene (1-38, 56 mg, 81%) was prepared in the same manner as in Example 35 as a yellow solid using 2-(2-chloropyrimidine-4-yl)-6-(3-fluoropropoxy)benzothiophene (105c, 70 mg, 0.22 mmol) obtained in Preparation Example 21 and a 2.0 M methylamine methanol solution (NH2Me in MeOH, 0.17 mL, 0.34 mmol).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08497260B2 |
| 출처 데이터셋 | uspto-grants-2013_07 |
| ORD ID | ord-5a8dd2395eee48f8be36faf4892656d1 |
| 출처 메모 | uspto-grants-2013_07 |