Dimethylamine methanol → 2-[2-(N,N-dimethylamino)pyrimidine-4-yl]-6-(3-fluoropropoxy)benzothiophene

참여 물질

역할	이름	HCID	투입량
반응물	Dimethylamine methanol	HCID 22497844	—
반응물	2-(2-Chloropyrimidine-4-yl)-6-(3-fluoropropoxy)benzothiophene	HCID 86646557	—
생성물	2-[2-(N,N-dimethylamino)pyrimidine-4-yl]-6-(3-fluoropropoxy)benzothiophene	HCID 46947729	70%

반응 단계

2-[2-(N,N-Dimethylamino)pyrimidine-4-yl]-6-(3-fluoropropoxy)benzothiophene (1-39, 50 mg, 70%) was prepared in the same manner as in Example 36 as a yellow solid using 2-(2-chloropyrimidine-4-yl)-6-(3-fluoro propoxy)benzothiophene (105c, 70 mg, 0.22 mmol) obtained in Preparation Example 21 and a 2.0 M dimethylamine methanol solution (NHMe2 in MeOH, 0.17 mL, 0.34 mmol).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08497260B2
출처 데이터셋	uspto-grants-2013_07
ORD ID	ord-88bf5b9b36a1453f9c4fe1d63f7373aa
출처 메모	uspto-grants-2013_07