3,6-Dichloropyridazine → 6-chloro-N,N-dimethylpyridazin-3-amine

반응식

[Cl:1][C:2]1[N:3]=[N:4][C:5](Cl)=[CH:6][CH:7]=1.CO.[CH3:11][NH:12][CH3:13]>>[CH3:11][N:12]([C:5]1[N:4]=[N:3][C:2]([Cl:1])=[CH:7][CH:6]=1)[CH3:13]

참가 물질

반응물 2

HCID 673313,6-Dichloropyridazine

HCID 22497844Dimethylamine methanol

생성물 1

HCID 2524746-chloro-N,N-dimethylpyridazin-3-amine수율 96.3%

실험 절차

3-(N,N-Dimethylamino)-6-chloropyridazine (108f, 510 mg, 96%) was prepared in the same manner as in Example 29 as a white solid using 3,6-dichloropyridazine (107, 500 mg, 3.36 mmol) and a 2.0 M dimethylamine methanol solution (NHMe2 in MeOH, 5 mL, 10 mmol).

출처 및 근거

ORD 기록: ord-3fdef52f4ff9423e9c292be350d38a88
출처 데이터셋: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08497260B2

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