Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Amino-4,6-difluoropyrimidine → N-((6-Chloro-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-4,6-difluoropyrimidin-2-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Amino-4,6-difluoropyrimidine | HCID 1201480 | — |
| 반응물 | 6-Chloro-3-(chloromethyl)-2-(4-fluorophenyl)imidazo[1,2-a]pyridine hydrochloride | HCID 67028637 | — |
| 생성물 | N-((6-Chloro-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-4,6-difluoropyrimidin-2-amine | HCID 67028720 | 45% |
반응 단계
The title compound was prepared according to Method A and the experimentals described for compound 139 from 6-chloro-3-(chloromethyl)-2-(4-fluorophenyl)imidazo[1,2-a]pyridine hydrochloride and 4,6-difluoropyrimidin-2-amine. (0.42 g, 45% yield). M/e+ 390.2 for C18H11ClF3N5 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08497278B2 |
| 출처 데이터셋 | uspto-grants-2013_07 |
| ORD ID | ord-a1f35b95f5704c358b84b911452bfbf2 |
| 출처 메모 | uspto-grants-2013_07 |