2-(Methylamino)ethanol → 2-((6-((2-(4-Chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)pyrazin-2-yl)(methyl)amino)ethanol

HRID 455113노트

반응식

HRID 455113 반응식
ClC1C=CC2N(C(CNC3N=C(N4CCC(C)(O)CC4)C=CN=3)=C(C3C=CC=CC=3)N=2)C=1.[Cl:33][C:34]1[CH:39]=[CH:38][C:37]([C:40]2[N:41]=[C:42]3[CH:47]=[CH:46][CH:45]=[CH:44][N:43]3[C:48]=2[CH2:49][C:50]2[CH:55]=[N:54][CH:53]=[C:52](Cl)[N:51]=2)=[CH:36][CH:35]=1.[CH3:57][NH:58][CH2:59][CH2:60][OH:61]>>[Cl:33][C:34]1[CH:39]=[CH:38][C:37]([C:40]2[N:41]=[C:42]3[CH:47]=[CH:46][CH:45]=[CH:44][N:43]3[C:48]=2[CH2:49][C:50]2[N:51]=[C:52]([N:58]([CH3:57])[CH2:59][CH2:60][OH:61])[CH:53]=[N:54][CH:55]=2)=[CH:36][CH:35]=1

참가 물질

4

반응물 3

HCID 80162-(Methylamino)ethanolHCID 670290991-(2-((6-Chloro-2-phenylimidazo[1,2-a]pyridin-3-yl)methylamino)pyrimidin-4-yl)-4-methylpiperidin-4-olHCID 866551242-(4-Chlorophenyl)-3-((6-chloropyrazin-2-yl)methyl)imidazo[1,2-a]pyridine

생성물 1

HCID 670275422-((6-((2-(4-Chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)pyrazin-2-yl)(methyl)amino)ethanol

실험 절차

The title compound was prepared according to the experimental for compound 187 from 2-(4-chlorophenyl)-3-((6-chloropyrazin-2-yl)methyl)imidazo[1,2-a]pyridine and 2-(methylamino)ethanol. M/e+ 394 for C21H21ClN5O (M+H)+; 1H-NMR (400 MHz, CDCl3) δ 8.06 (d, J=6.6 Hz, 1H), 7.89 (s, 1H), 7.78 (d, J=8.4 Hz, 2H), 7.70 (s, 1H), 7.60 (dd, J=8.4, 0.7 Hz, 1H), 7.40 (d, J=8.4 Hz, 2H), 7.17 (m, 1H), 6.77 (t, J=6.9 Hz, 1H), 4.34 (s, 2H), 3.64 (t, J=5.1 Hz, 2H), 3.54 (t, J=5.1 Hz, 2H), 3.05 (s, 3H) ppm.

출처 및 근거

ORD 기록
ord-a2851c04125e4ac689ea2699e2d956c6
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08497278B2

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