Bromoacetonitrile → (S)-N-((S)-1-(5-bromo-2-(methoxymethoxy)phenyl)-1-(3-chloro-2-fluoro-6-morpholinopyridin-4-yl)-2-(cyanomethoxy)ethyl)-2-methylpropane-2-sulfinamide

HRID 455692노트

반응식

HRID 455692 반응식
O.[OH-].[Li+].[Br:4][C:5]1[CH:6]=[CH:7][C:8]([O:35][CH2:36][O:37][CH3:38])=[C:9]([C@:11]([NH:28][S@:29]([C:31]([CH3:34])([CH3:33])[CH3:32])=[O:30])([C:14]2[CH:19]=[C:18]([N:20]3[CH2:25][CH2:24][O:23][CH2:22][CH2:21]3)[N:17]=[C:16]([F:26])[C:15]=2[Cl:27])[CH2:12][OH:13])[CH:10]=1.Br[CH2:40][C:41]#[N:42].[Cl-].[NH4+]>C1COCC1>[Br:4][C:5]1[CH:6]=[CH:7][C:8]([O:35][CH2:36][O:37][CH3:38])=[C:9]([C@:11]([NH:28][S@:29]([C:31]([CH3:32])([CH3:33])[CH3:34])=[O:30])([C:14]2[CH:19]=[C:18]([N:20]3[CH2:25][CH2:24][O:23][CH2:22][CH2:21]3)[N:17]=[C:16]([F:26])[C:15]=2[Cl:27])[CH2:12][O:13][CH2:40][C:41]#[N:42])[CH:10]=1

참가 물질

6

반응물 4

HCID 11534BromoacetonitrileHCID 25517Ammonium ChlorideHCID 168937Lithium hydroxide, monohydrateHCID 67440021(S)-N-((S)-1-(5-bromo-2-(methoxymethoxy)phenyl)-1-(3-chloro-2-fluoro-6-morpholinopyridin-4-yl)-2-hydroxyethyl)-2-methylpropane-2-sulfinamide

생성물 1

HCID 67438635(S)-N-((S)-1-(5-bromo-2-(methoxymethoxy)phenyl)-1-(3-chloro-2-fluoro-6-morpholinopyridin-4-yl)-2-(cyanomethoxy)ethyl)-2-methylpropane-2-sulfinamide수율 74.7%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Lithium hydroxide hydrate (0.402 g, 9.58 mmol) was added to a solution of (S)—N—((S)-1-(5-bromo-2-(methoxymethoxy)phenyl)-1-(3-chloro-2-fluoro-6-morpholinopyridin-4-yl)-2-hydroxyethyl)-2-methylpropane-2-sulfinamide (1.9 g, 3.19 mmol) in THF (25 mL) at RT, followed by bromoacetonitrile (0.445 mL, 6.39 mmol). The reaction mixture was allowed to stir at RT for 12 h. The reaction mixture was treated with aqueous saturated ammonium chloride, and the mixture was extracted with EtOAc. The organic phase was washed with water, brine, dried over MgSO4 and then concentrated under reduced pressure. The remaining residue was purified by silica gel chromatography (50-100% EtOAc/hexanes) to afford 1.51 g of (S)—N—((S)-1-(5-bromo-2-(methoxymethoxy)phenyl)-1-(3-chloro-2-fluoro-6-morpholinopyridin-4-yl)-2-(cyanomethoxy)ethyl)-2-methylpropane-2-sulfinamide.

후처리

  1. extractionthe mixture was extracted with EtOAc
  2. washThe organic phase was washed with water, brine
  3. dry with materialdried over MgSO4
  4. concentrationconcentrated under reduced pressure
  5. customThe remaining residue was purified by silica gel chromatography (50-100% EtOAc/hexanes)

출처 및 근거

ORD 기록
ord-57e531de927f41e192bd3453b04ddd58
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08497264B2

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