Hydrazine hydrate (1:1) → 1-(Quinolin-6-yl)cyclopropanecarbohydrazide

HRID 456114노트

반응식

HRID 456114 반응식
C[O:2][C:3]([C:5]1([C:8]2[CH:9]=[C:10]3[C:15](=[CH:16][CH:17]=2)[N:14]=[CH:13][CH:12]=[CH:11]3)[CH2:7][CH2:6]1)=O.O.[NH2:19][NH2:20]>CO>[N:14]1[C:15]2[C:10](=[CH:9][C:8]([C:5]3([C:3]([NH:19][NH2:20])=[O:2])[CH2:7][CH2:6]3)=[CH:17][CH:16]=2)[CH:11]=[CH:12][CH:13]=1

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 58190477Methyl 1-(quinolin-6-yl)cyclopropanecarboxylate

생성물 1

HCID 669271581-(Quinolin-6-yl)cyclopropanecarbohydrazide수율 100%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of 1-quinolin-6-yl-cyclopropanecarboxylic acid methyl ester (513 mg, 2.26 mmol) and hydrazine monohydrate (3.39 g, 67.7 mmol) in methanol (5 mL) was heated under reflux overnight. After cooling, the solvent was removed in vacuo to afford 513 mg (100%) of the title compound and used without further purification. LCMS (method A): [MH]+=228, tR=2.88 min.

후처리

  1. temperatureunder reflux overnight
  2. temperatureAfter cooling
  3. customthe solvent was removed in vacuo

출처 및 근거

ORD 기록
ord-a43a402029b649049326699f8de4c99d
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08497368B2

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