Methylamine → 3-hydroxy-N-methylbenzamide

HRID 456396

반응식

HRID 456396 반응식
[OH:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5](O)=[O:6].[CH3:11][NH2:12]>>[OH:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([NH:12][CH3:11])=[O:6]

참가 물질

3

반응물 2

HCID 6329MethylamineHCID 74203-Hydroxybenzoic Acid

생성물 1

HCID 3537103-hydroxy-N-methylbenzamide수율 91.5%

실험 절차

A mixture of 3-hydroxybenzoic acid (1.3 g, 9.4 mmol) and a ethanolic methylamine solution (33%, 1.5 ml, 12.1 mmol) were stirred at 60° C. for 48 h, then the solvent was evaporated in vacuo, and the residue redissolved in a small volume of ethanol. The product precipitated from the solution by the addition of ethyl acetate. The precipitate was collected by filtration and dried to give the subtitled compound (1.3 g, 91%).

후처리

  1. customthe solvent was evaporated in vacuo
  2. dissolutionthe residue redissolved in a small volume of ethanol
  3. customThe product precipitated from the solution by the addition of ethyl acetate
  4. filtrationThe precipitate was collected by filtration
  5. customdried

출처 및 근거

ORD 기록
ord-0a298d99e03a41c588c18607c8b057ee
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07186718B2

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