Methylamine → 3-hydroxy-N-methylbenzamide

반응식

[OH:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5](O)=[O:6].[CH3:11][NH2:12]>>[OH:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([NH:12][CH3:11])=[O:6]

참가 물질

반응물 2

HCID 6329Methylamine

HCID 74203-Hydroxybenzoic Acid

생성물 1

HCID 3537103-hydroxy-N-methylbenzamide수율 91.5%

실험 절차

A mixture of 3-hydroxybenzoic acid (1.3 g, 9.4 mmol) and a ethanolic methylamine solution (33%, 1.5 ml, 12.1 mmol) were stirred at 60° C. for 48 h, then the solvent was evaporated in vacuo, and the residue redissolved in a small volume of ethanol. The product precipitated from the solution by the addition of ethyl acetate. The precipitate was collected by filtration and dried to give the subtitled compound (1.3 g, 91%).

후처리

customthe solvent was evaporated in vacuo
dissolutionthe residue redissolved in a small volume of ethanol
customThe product precipitated from the solution by the addition of ethyl acetate
filtrationThe precipitate was collected by filtration
customdried

출처 및 근거

ORD 기록: ord-0a298d99e03a41c588c18607c8b057ee
출처 데이터셋: uspto-grants-2007_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07186718B2

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