Lithium Hydroxide → [4-(3,3-diphenyl-propionyl)-piperazin-1-yl]-acetic Acid

HRID 456429노트

반응식

HRID 456429 반응식
C([O:3][C:4](=[O:28])[CH2:5][N:6]1[CH2:11][CH2:10][N:9]([C:12](=[O:27])[CH2:13][CH:14]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:8][CH2:7]1)C.[Li+].[OH-]>CO.O>[C:21]1([CH:14]([C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH2:13][C:12]([N:9]2[CH2:10][CH2:11][N:6]([CH2:5][C:4]([OH:28])=[O:3])[CH2:7][CH2:8]2)=[O:27])[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1

참가 물질

4

반응물 2

HCID 3939Lithium HydroxideHCID 58817810[4-(3,3-diphenyl-propionyl)-piperazin-1-yl]-acetic Acid Ethyl Ester

생성물 1

HCID 18437004[4-(3,3-diphenyl-propionyl)-piperazin-1-yl]-acetic Acid수율 78%

시약·촉매·용매 1

HCID 22242641Methanol--water (1/1)용매

실험 절차

A mixture of [4-(3,3-diphenyl-propionyl)-piperazin-1-yl]-acetic acid ethyl ester (1.17 g, 3.07 mmol) and LiOH (645 mg, 15.35 mmol) in MeOH: H2O (3:1, 40 ml) stirred at room temperature for 2 days. The solvent was then evaporated and residue dissolved in water. Upon acidified with 2N HCl to pH 3, product precipitated in aq. phase, filtered and washed few times with water and dried to give the desired product in 78% yield.

후처리

  1. customThe solvent was then evaporated
  2. dissolutionresidue dissolved in water
  3. customprecipitated in aq. phase
  4. filtrationfiltered
  5. washwashed few times with water
  6. customdried

출처 및 근거

ORD 기록
ord-ab4b2667b017452a9e359a6229a1bf05
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07186726B2

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