Hydrazine hydrate (1:1) → HCID 178420814, 화합물
반응식
Cl[C:2]1[C:7]([C:8]([C:10]2[NH:11][CH:12]=[CH:13][CH:14]=2)=O)=[CH:6][CH:5]=[CH:4][N:3]=1.O.[NH2:16][NH2:17]>C(O)C>[NH:11]1[CH:12]=[CH:13][CH:14]=[C:10]1[C:8]1[C:7]2[C:2](=[N:3][CH:4]=[CH:5][CH:6]=2)[NH:17][N:16]=1참가 물질
4
실험 절차
A mixture of (2-chloro-pyridin-3-yl)-(1H-pyrrol-2-yl)-methanone (1 g, 4.8 mmol) and hydrazine hydrate (0.5 mL) in ethanol (15 mL) was heated to reflux for overnight. The reaction was concentrated and the residue was triturated with dichloromethane (to remove any unreacted starting material. The solid was filtered, washed wit water and dried to give 720 mg (81%) of the titled compound as a light yellow solid.
후처리
- temperaturewas heated
- temperatureto reflux for overnight
- concentrationThe reaction was concentrated
- customthe residue was triturated with dichloromethane (
- customto remove
- filtrationThe solid was filtered
- washwashed wit water
- customdried
출처 및 근거
- ORD 기록
- ord-f9cb4e804a964e21ab90878eeb1e1b60
- 출처 데이터셋
- uspto-grants-2007_03
- 특허 번호
- US07186716B2
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