Hydrazine hydrate (1:1) → HCID 178527562, 화합물

HRID 456642노트

반응식

HRID 456642 반응식
[CH2:1]([NH:8][S:9]([C:12]1[CH:16]=[C:15]([C:17]([C:19]2[C:20](Cl)=[N:21][CH:22]=[CH:23][CH:24]=2)=O)[NH:14][CH:13]=1)(=[O:11])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O.[NH2:27][NH2:28]>C(O)C>[CH2:1]([NH:8][S:9]([C:12]1[CH:16]=[C:15]([C:17]2[C:19]3[C:20](=[N:21][CH:22]=[CH:23][CH:24]=3)[NH:28][N:27]=2)[NH:14][CH:13]=1)(=[O:11])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 865922435-(2-chloro-pyridine-3-carbonyl)1H-pyrrole-3-sulfonic acid benzylamide

생성물 1

HCID 178527562HCID 178527562, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
80 °C

실험 절차

A mixture of 5-(2-chloro-pyridine-3-carbonyl)-1H-pyrrole-3-sulfonic acid benzylamide (100 mg), hydrazine hydrate (excess) in ethanol (10 mL) was heated at 80° C. for 48 hours. The reaction was concentrated, mixed with water, the precipitate was filtered off, the filtrate was washed with dilute HCl, water, dried and concentrated to give the titled compound as a light yellow solid.

후처리

  1. concentrationThe reaction was concentrated
  2. additionmixed with water
  3. filtrationthe precipitate was filtered off
  4. washthe filtrate was washed with dilute HCl, water
  5. customdried
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-2a1b0aeb7f674e26a6736595803bf2a1
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07186716B2

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