Water → HCID 178527393, 화합물

HRID 456681노트

반응식

HRID 456681 반응식
[Cl:1][C:2]1[CH:25]=[CH:24][C:5]([CH2:6][S:7]([C:10]2[CH:11]=[C:12]([C:15]([C:17]3[C:18](Cl)=[N:19][CH:20]=[CH:21][CH:22]=3)=O)[NH:13][CH:14]=2)(=[O:9])=[O:8])=[CH:4][CH:3]=1.O.[NH2:27][NH2:28].O>C(O)C>[Cl:1][C:2]1[CH:25]=[CH:24][C:5]([CH2:6][S:7]([C:10]2[CH:11]=[C:12]([C:15]3[C:17]4[C:18](=[N:19][CH:20]=[CH:21][CH:22]=4)[NH:28][N:27]=3)[NH:13][CH:14]=2)(=[O:9])=[O:8])=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 24654Hydrazine hydrate (1:1)HCID 18436879{4-[(4-chlorobenzyl)sulfonyl]-1H-pyrrol-2-yl}(2-chloropyridin-3-yl)methanone

생성물 1

HCID 178527393HCID 178527393, 화합물수율 95%

시약·촉매·용매 1

HCID 702Ethanol용매

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온도
80 °C

실험 절차

{4-[(4-chlorobenzyl)sulfonyl]-1H-pyrrol-2-yl}(2-chloropyridin-3-yl)methanone (280 mg, 0.711 mmol) and 359 mg of hydrazine monohydrate (7.11 mmol) were mixed in 4 mL of ethanol. The mixture was stirred at 80° C. overnight (16 hour) and then cooled down to room temperature. Water was added and filtered. Washed with additional water and methanol to collect the product, dried to afford 250 mg (95% yield) of the title compound.

후처리

  1. temperaturecooled down to room temperature
  2. filtrationfiltered
  3. washWashed with additional water and methanol
  4. customto collect the product
  5. customdried

출처 및 근거

ORD 기록
ord-b4cd261dd8044ae3a7e767a86bf535b7
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07186716B2

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