Sodium Hydroxide → (2S,4S)-1-((tert-butoxy)carbonyl)-4-fluoropyrrolidine-2-carboxylic acid

HRID 456736노트

반응식

HRID 456736 반응식
[F:1][C@@H:2]1[CH2:6][N:5]([C:7]([O:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:8])[C@H:4]([C:14]([O:16]C)=[O:15])[CH2:3]1.[OH-].[Na+]>CO>[C:10]([O:9][C:7]([N:5]1[CH2:6][C@@H:2]([F:1])[CH2:3][C@H:4]1[C:14]([OH:16])=[O:15])=[O:8])([CH3:13])([CH3:11])[CH3:12]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 10977773(2S,4S)-1-Tert-butyl 2-methyl 4-fluoropyrrolidine-1,2-dicarboxylate

생성물 1

HCID 2756017(2S,4S)-1-((tert-butoxy)carbonyl)-4-fluoropyrrolidine-2-carboxylic acid

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

The crude product of 1-tert-butyl 2-methyl (2S,4S)-4-fluoro-1,2-pyrrolidinedicarboxylate obtained in Example 7-6 (127.5 g) was dissolved in methanol (400 mL) and then 1N NaOH (800 mL) was added at room temperature.

출처 및 근거

ORD 기록
ord-b45e5f7edcba4250ba9ec65e5f3eb41f
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07186731B2

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