Hydrochloric Acid → 1-Benzyl-4-methylpiperidin-4-amine

반응식

[CH2:1]([N:8]1[CH2:13][CH2:12][C:11]([NH:15]C(=O)C)([CH3:14])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl>>[CH2:1]([N:8]1[CH2:13][CH2:12][C:11]([CH3:14])([NH2:15])[CH2:10][CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

반응물 2

HCID 313Hydrochloric Acid

HCID 21472469n-(1-Benzyl-4-methylpiperidin-4-yl)acetamide

생성물 1

HCID 221467251-Benzyl-4-methylpiperidin-4-amine수율 100%

실험 절차

A mixture of N-(1-benzyl-4-methyl-4-piperidinyl)acetamide obtained in Example 10-2 (3.45 g) and conc. HCl (41 mL) was heated under reflux with stirring for 72 hrs. After cooling, the mixture was quenched by adding 3N potassium hydroxide solution, and the resulting solution (pH11) was extracted with chloroform. The organic layer was washed with brine, dried over MgSO4, and concentrated to give the title compound as a pale brown oil (2.86 g).

후처리

temperaturewas heated
temperatureunder reflux
temperatureAfter cooling
customthe mixture was quenched
additionby adding 3N potassium hydroxide solution
extractionthe resulting solution (pH11) was extracted with chloroform
washThe organic layer was washed with brine
dry with materialdried over MgSO4
concentrationconcentrated

출처 및 근거

ORD 기록: ord-13b9a379efaa49a4be83c134ec18a6cd
출처 데이터셋: uspto-grants-2007_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07186731B2

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