Allyl bromide → Methyl 2-(allyloxy)-4-methoxybenzoate

HRID 456804

반응식

HRID 456804 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([OH:13])[C:6](=[CH:11][CH:12]=1)[C:7]([O:9][CH3:10])=[O:8].C([O-])([O-])=O.[Cs+].[Cs+].[CH2:20](Br)[CH:21]=[CH2:22]>CCOC(C)=O>[CH2:22]([O:13][C:5]1[CH:4]=[C:3]([O:2][CH3:1])[CH:12]=[CH:11][C:6]=1[C:7]([O:9][CH3:10])=[O:8])[CH:21]=[CH2:20]

참가 물질

5

반응물 3

HCID 7841Allyl bromideHCID 10796Cesium carbonateHCID 79523Methyl 4-methoxysalicylate

생성물 1

HCID 10242646Methyl 2-(allyloxy)-4-methoxybenzoate

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

To a solution of methyl 4-methoxysalicylate (2.0 g, 11 mmol) in DMP (20 mL) at room temperature was added Cs2CO3 (1.3 eq, 4.7 g) and allyl bromide (1.3 eq, 1.23 mL). After 2 hr, reaction mixture was diluted with EtOAc and washed with water (3×), brine (1×). The organic layer was dried over Na2SO4 and concentrated to provide the product as a pale yellow oil. Product was used without further purification.

후처리

  1. customreaction mixture
  2. washwashed with water (3×), brine (1×)
  3. dry with materialThe organic layer was dried over Na2SO4
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-78a6b749accd43fcb538a702fbbb6bdf
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07186746B2

연결된 노트

불러오는 중…