Bromine → 5-Bromo-2-methanesulfonyl-6-methoxy-quinoline

HRID 456989

반응식

HRID 456989 반응식
[CH3:1][S:2]([C:5]1[CH:14]=[CH:13][C:12]2[C:7](=[CH:8][CH:9]=[C:10]([O:15][CH3:16])[CH:11]=2)[N:6]=1)(=[O:4])=[O:3].[Br:17]Br.C([O-])(O)=O.[Na+].S([O-])([O-])(=O)=S.[Na+].[Na+]>C(Cl)Cl>[Br:17][C:11]1[C:10]([O:15][CH3:16])=[CH:9][CH:8]=[C:7]2[C:12]=1[CH:13]=[CH:14][C:5]([S:2]([CH3:1])(=[O:4])=[O:3])=[N:6]2

참가 물질

6

반응물 4

HCID 24408BromineHCID 24477Sodium ThiosulfateHCID 516892Sodium BicarbonateHCID 112533772-Methanesulfonyl-6-methoxy-quinoline

생성물 1

HCID 221397325-Bromo-2-methanesulfonyl-6-methoxy-quinoline

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of 2-methanesulfonyl-6-methoxy-quinoline (237 mg, 1 mmole ) in CH2Cl2 was treated with 2 mmoles Br2 and stirred for 1 day. The mixture was poured into a solution of NaHCO3 and sodium thiosulfate. The product was extracted with CH2Cl2. The organic layer was dried and evaporated to afford 5-bromo-2-methanesulfonyl-6-methoxy-quinoline, 287 mg (91%), as white crystals.

후처리

  1. extractionThe product was extracted with CH2Cl2
  2. customThe organic layer was dried
  3. customevaporated

출처 및 근거

ORD 기록
ord-e1f3bbba8e15440082e249eeef0fb0a8
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07186840B2

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