Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
5-(2,4-Difluoro-phenylsulfanyl)-2-methanesulfonyl-6-methoxy-quinoline → 5-(2,4-Difluoro-benzenesulfinyl)-2-methanesulfonyl-6-methoxy-quinoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 5-(2,4-Difluoro-phenylsulfanyl)-2-methanesulfonyl-6-methoxy-quinoline | HCID 9864712 | — |
| 반응물 | Potassium hydroxy sulfite | HCID 23707502 | — |
| 용매 | Methanol tetrahydrofuran water | HCID 21892291 | — |
| 생성물 | 5-(2,4-Difluoro-benzenesulfinyl)-2-methanesulfonyl-6-methoxy-quinoline | HCID 22139740 | 45.9% |
반응 단계
5-(2,4-Difluoro-phenylsulfanyl)-2-methanesulfonyl-6-methoxy-quinoline 101 (230 mg) was dissolved in 9 mL (1:1:1 MeOH/THF/H2O) and was treated with 1 gram of OXONE™. After 3 hours the mixture was partitioned between CH2Cl2 and water. The product was purified by chromatography (10% MeOH/CH2Cl2) to afford 110 mg of 5-(2,4-difluoro-benzenesulfinyl)-2-methanesulfonyl-6-methoxy-quinoline 301; ([M+H]+)=398.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07186840B2 |
| 출처 데이터셋 | uspto-grants-2007_03 |
| ORD ID | ord-450de943c60345179af302675b43c965 |
| 출처 메모 | uspto-grants-2007_03 |