Cyclopropylamine → HCID 178418548, 화합물

반응식

[CH:1]([O-:6])([O-])[O:2][CH2:3][CH3:4].[F:7][C:8]1[CH:21]=[C:20]([N:22]2[CH:26]=[CH:25][CH:24]=[CH:23]2)[C:19]([F:27])=[CH:18][C:9]=1[C:10]([CH2:12][C:13](OCC)=O)=[O:11].[CH:28]1([NH2:31])[CH2:30][CH2:29]1>C(OC(=O)C)(=O)C>[CH:28]1([NH:31][CH:13]=[C:12]([C:10](=[O:11])[C:9]2[CH:18]=[C:19]([F:27])[C:20]([N:22]3[CH:23]=[CH:24][CH:25]=[CH:26]3)=[CH:21][C:8]=2[F:7])[C:1]([O:2][CH2:3][CH3:4])=[O:6])[CH2:30][CH2:29]1

참가 물질

실험 절차

1 g (0.0068 mol) of ethyl orthoformate is added to a solution of 1.1 g (0.00315 mol) of ethyl 2,5-difluoro-4-(pyrrol-1-yl)benzoylacetate in 3 ml of acetic anhydride and the mixture is refluxed for 3 hours. It is evaporated to dryness, the residue is dissolved in 10 ml of ethanol, 0.3 ml (0.0034 mol) of cyclopropylamine is added and the mixture is left at room temperature for 1 hour. It is evaporated to dryness and the oily residue is extracted with 3×30 ml of boiling hexane. The hexane fractions are concentrated to 20 ml and left for 12 hours at 5° C. to give 0.41 g of crystals melting at 90°-2° C.