Potassium Cyanide → 5-Cyanoethyl-2-oxindole

HRID 457668노트

반응식

HRID 457668 반응식
[C-:1]#[N:2].[K+].Cl[CH2:5][CH2:6][C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][CH:15]=1)[NH:12][C:11](=[O:16])[CH2:10]2>CS(C)=O>[C:1]([CH2:5][CH2:6][C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][CH:15]=1)[NH:12][C:11](=[O:16])[CH2:10]2)#[N:2]

참가 물질

4

반응물 2

HCID 9032Potassium CyanideHCID 145813925-(2-Chloroethyl)Oxindole

생성물 1

HCID 101764305-Cyanoethyl-2-oxindole수율 42%

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매2회

반응 조건

온도
90 °C

실험 절차

Potassium cyanide (2.0 g) was added to 15 mL of dimethyl-sulfoxide and heated to 90° C. 5-Chloroethyl-2-oxindole (3.0 g) dissolved in 5 mL dimethyl sulfoxide was added slowly with stirring, and the reaction heated to 150° C. for 2 hours. The mixture was cooled, poured into ice water and the precipitate collected by vacuum filtration, washed with water, dried and then chromatographed on silica gel (5% methanol in chloroform) to give 1.2 g (42% yield) of the title compound.

후처리

  1. additionwas added slowly
  2. temperaturethe reaction heated to 150° C. for 2 hours
  3. temperatureThe mixture was cooled
  4. filtrationthe precipitate collected by vacuum filtration
  5. washwashed with water
  6. customdried
  7. customchromatographed on silica gel (5% methanol in chloroform)

출처 및 근거

ORD 기록
ord-c77dba223207465db41690a6ced2795c
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07189721B2

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