반응식
[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][CH:9]([C:12]2[C:20]3[C:15](=[CH:16][C:17]([F:21])=[CH:18][CH:19]=3)[NH:14][CH:13]=2)[CH2:8][CH2:7]1)=[O:5])[CH3:2].CS(O[CH2:27][CH2:28][C:29]1[CH:33]=[CH:32][S:31][CH:30]=1)(=O)=O>>[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][CH:9]([C:12]2[C:20]3[C:15](=[CH:16][C:17]([F:21])=[CH:18][CH:19]=3)[N:14]([CH2:27][CH2:28][C:29]3[CH:33]=[CH:32][S:31][CH:30]=3)[CH:13]=2)[CH2:8][CH2:7]1)=[O:5])[CH3:2]참가 물질
3
반응 조건
- 온도
- 60 °C
실험 절차
This compound was prepared following the procedure described in example 13 (part B) starting with 4 g (13.8 mmol) of 4-(6-fluoro-1H-indol-3-yl)-piperidine-1-carboxylic acid ethyl ester (example 24, part A) and 3.3 g (16 mmol) of 2-thiophen-3-yl-ethyl methansulfonate. The reaction mixture was stirred at 60° C. for 3 hours. After standard work-up, 5.6 g (100% of yield) of 4-[6-fluoro-1-(2-thiophen-3-yl-ethyl)-1H-indol-3-yl]-piperidine-1-carboxylic acid ethyl ester were obtained.
후처리
- customThis compound was prepared
출처 및 근거
- ORD 기록
- ord-de6761be560c4262a651feeb08deebc2
- 출처 데이터셋
- uspto-grants-2007_03
- 특허 번호
- US07189741B2
연결된 노트
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