5-Chlorosalicylic Acid → 5-Chloro-2-hydroxybenzoyl chloride
반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:11])=[C:6]([CH:10]=1)[C:7](O)=[O:8].S(Cl)([Cl:14])=O>CCCCCCC>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:11])=[C:6]([CH:10]=1)[C:7]([Cl:14])=[O:8]참가 물질
4
반응 조건
- 온도
- 60 °C
실험 절차
A solution of 5-chloro-2-hydroxy-benzoic acid (20.0 g, 116 mmol) in heptane (232 mL, 0.5 M) was treated with thionyl chloride (25.4 mL, 348 mmol) and heated to 60° C. for 6 h. After cooling to room temperature, the solution was concentrated under reduced pressure to give 5-chloro-2-hydroxy-benzoyl chloride as a thick yellow oil (22 g) which was used without further purification.
후처리
- temperatureAfter cooling to room temperature
- concentrationthe solution was concentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-a2eab2155d4c4b518cbf2bcd1b497a70
- 출처 데이터셋
- uspto-grants-2007_03
- 특허 번호
- US07189749B2
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