Hydrochloric Acid → 2-(Isopropylsulfonyl)ethanamine

HRID 458088

반응식

HRID 458088 반응식
[CH:1]([S:4]([CH2:7][C:8]#[N:9])(=[O:6])=[O:5])([CH3:3])[CH3:2].CSC.B.Cl>C1COCC1>[CH:1]([S:4]([CH2:7][CH2:8][NH2:9])(=[O:6])=[O:5])([CH3:3])[CH3:2]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 27785302-(Isopropylsulfonyl)acetonitrileHCID 12423031(Dimethyl sulfide)trihydroboron

생성물 1

HCID 220177492-(Isopropylsulfonyl)ethanamine

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Prepared according to Procedure K. 2-iso-Propylsulfonylacetonitrile (0.50 g, 3.39 mmol) was dissolved in THF and warmed to reflux under N2. Borane dimethylsulfide (2M, 1.7 mL, 3.39 mmol) was added dropwise and the reaction was stirred for an additional 40 minutes at reflux. After cooling the reaction to rt, HCl (2 M in MeOH) was added to the reaction slowly due to gas evolution. The volatiles were removed and frexh methanol was added to the resulting residue. Again, the volatiles were removed and the resulting residue was taken up in CH2Cl2 (25 mL) and washed with saturated potassium carbonate (aqueous). The organic layer was dried over sodium sulfate and the volatiles were removed to afford the title compound. GC-MS m/z 152 (MH+).

후처리

  1. customPrepared
  2. temperaturewarmed
  3. temperatureto reflux under N2
  4. temperatureat reflux
  5. temperatureAfter cooling
  6. customthe reaction to rt
  7. customThe volatiles were removed
  8. additionfrexh methanol was added to the resulting residue
  9. customAgain, the volatiles were removed
  10. washwashed with saturated potassium carbonate (aqueous)
  11. dry with materialThe organic layer was dried over sodium sulfate
  12. customthe volatiles were removed

출처 및 근거

ORD 기록
ord-3fe05e38b9c843a6a6664e4f6a845de0
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07189734B2

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