Hydrochloric Acid → (2S)-2-(2,3,4-trifluoroanilino)propionic acid

HRID 458175

반응식

HRID 458175 반응식
[F:1][C:2]1[C:13]([F:14])=[C:12]([F:15])[CH:11]=[CH:10][C:3]=1[NH:4][C@@H:5]([CH3:9])[C:6]([OH:8])=[O:7].C1([C@@H](N)C)C=CC=CC=1.Cl>>[F:1][C:2]1[C:13]([F:14])=[C:12]([F:15])[CH:11]=[CH:10][C:3]=1[NH:4][C@@H:5]([CH3:9])[C:6]([OH:8])=[O:7]

참가 물질

3

반응물 2

HCID 313Hydrochloric AcidHCID 67369703HCID 67369703, 화합물

생성물 1

HCID 67366567(2S)-2-(2,3,4-trifluoroanilino)propionic acid수율 96%

실험 절차

To (2S)-2-(2,3,4-trifluoroanilino)propionic acid•(S)-1-phenylethylamine salt (1.0 g; 99% ee) were added IPE (20 ml) and hydrochloric acid (1 mol/l) until the pH value reached 1 and the resultant mixture was stirred at room temperature for 1 hour. The organic layer was dried over anhydrous magnesium sulfate. After evaporating the solvent, 618 mg of the title compound was obtained as colorless crystals. The optical purity of this product was 99% ee. The 1H-NMR and IR spectral data of this product was identical with those of the compound obtained in Example 23.

후처리

  1. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  2. customAfter evaporating the solvent

출처 및 근거

ORD 기록
ord-13c76af55b6d416fb24bc04ff8a3e530
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07189847B2

연결된 노트

불러오는 중…