Hydrochloric Acid → 4-Chloromethyl-2-methoxy-1-pent-2-ynyloxy-benzene

HRID 458245노트

반응식

HRID 458245 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:15]O)[CH:6]=[CH:7][C:8]=1[O:9][CH2:10][C:11]#[C:12][CH2:13][CH3:14].[ClH:17]>O1CCOCC1>[Cl:17][CH2:15][C:5]1[CH:6]=[CH:7][C:8]([O:9][CH2:10][C:11]#[C:12][CH2:13][CH3:14])=[C:3]([O:2][CH3:1])[CH:4]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 18442092(3-Methoxy-4-pent-2-ynyloxy-phenyl)-methanol

생성물 1

HCID 184420934-Chloromethyl-2-methoxy-1-pent-2-ynyloxy-benzene

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

A solution of (3-methoxy-4-pent-2-ynyloxy-phenyl)-methanol (27 g, 0.12 mol) in 450 ml of dioxan is added dropwise to 240 ml of concentrated hydrochloric acid. The reaction mixture is stirred for 1.5 hours at room temperature. Subsequently it is poured on water and extracted with ethyl acetate. The combined organic layer is washed with brine, dried over magnesium sulfate and evaporated in vacuo to obtain 4-chloromethyl-2-methoxy-1-pent-2-ynyloxy-benzene as yellow oil.

후처리

  1. additionSubsequently it is poured on water
  2. extractionextracted with ethyl acetate
  3. washThe combined organic layer is washed with brine
  4. dry with materialdried over magnesium sulfate
  5. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-7a630b6eee2b467e860d1d0089b0a612
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07189873B2

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