4-(Trifluoromethyl)-2,3,5,6-tetrafluorobenzyl bromide → 2-Methoxy-5-(2,3,5,6-tetrafluoro-4-trifluoromethylbenzylamino)benzoic acid

HRID 458264

반응식

HRID 458264 반응식
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([O:11][CH3:12])=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8].[F:13][C:14]1[C:21]([F:22])=[C:20]([C:23]([F:26])([F:25])[F:24])[C:19]([F:27])=[C:18]([F:28])[C:15]=1[CH2:16]Br>CN(C=O)C>[CH3:12][O:11][C:5]1[CH:4]=[CH:3][C:2]([NH:1][CH2:16][C:15]2[C:18]([F:28])=[C:19]([F:27])[C:20]([C:23]([F:24])([F:26])[F:25])=[C:21]([F:22])[C:14]=2[F:13])=[CH:10][C:6]=1[C:7]([OH:9])=[O:8]

참가 물질

4

반응물 2

HCID 1271374-(Trifluoromethyl)-2,3,5,6-tetrafluorobenzyl bromideHCID 135492445-Amino-2-methoxybenzoic acid

생성물 1

HCID 100463322-Methoxy-5-(2,3,5,6-tetrafluoro-4-trifluoromethylbenzylamino)benzoic acid수율 31.5%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

According to the similar procedure in Synthesis Example 1, by using 5-amino-2-methoxy-benzoic acid (2.10 g, 12.7 mmole), DMF (50 ml), TEA (6 ml), and 2,3,5,6-tetrafluoro-4-trifluoromethylbenzyl bromide (2.00 ml, 14.0 mmole), 1.50 g (31.5% yield) of 2-methoxy-5-(2,3,5,6-tetrafluoro-4-trifluoromethylbenzylamino)benzoic acid was obtained as a yellow solid:

후처리

  1. customAccording to the similar procedure in Synthesis Example 1

출처 및 근거

ORD 기록
ord-4e81a2907878426d8e423b4fba2a6471
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07189878B2

연결된 노트

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