2-(1,3-Dioxolan-2-yl)-1,3-thiazole-5-carboxylic acid → 2-Formylthiazole-5-carboxylic acid

HRID 458423노트

반응식

HRID 458423 반응식
[O:1]1CCO[CH:2]1[C:6]1[S:7][C:8]([C:11]([OH:13])=[O:12])=[CH:9][N:10]=1>Cl>[CH:2]([C:6]1[S:7][C:8]([C:11]([OH:13])=[O:12])=[CH:9][N:10]=1)=[O:1]

참가 물질

3

반응물 1

HCID 184418922-(1,3-Dioxolan-2-yl)-1,3-thiazole-5-carboxylic acid

생성물 1

HCID 184418962-Formylthiazole-5-carboxylic acid수율 91.4%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

2-(1,3-dioxolan-2-yl)-1,3-thiazole-5-carboxylic acid (1.40 g, 6.96 mmol) was dissolved in 15 mL of 6N HCl and heated to reflux for 30 min and then cooled to ambient temperature. The organics were extracted twice with EtOAc and then dried(Na2SO4), filtered and concentrated to give the title compound (1.00 g, 6.36 mmol, 91% yield) as an orange solid. 1H NMR (CDCl3, 400 MHz) δ 10.0 (s, 1H), 8.66 (s, 1H), 6.70–6.00 (bs, 1H).

후처리

  1. temperatureheated
  2. temperatureto reflux for 30 min
  3. extractionThe organics were extracted twice with EtOAc
  4. filtrationdried(Na2SO4), filtered
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-b805159e456a4d82a2ccd748f1b83963
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07189851B2

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