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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Furfurylamine → Ethyl 2-(4-fluorobenzyl)-4-(6-{[(2-furylmethyl)amino]carbonyl}-3-pyridazinyl)-5-oxo-7,8,9,9a-tetrahydro-5H-pyrido[2,3-alpha]pyrrolizine-3-carboxylate

HRID 458451
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HRID 458451 반응식
[CH2:1]([O:3][C:4]([C:6]1[C:18]([CH2:19][C:20]2[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=2)=[N:17][C:9]2[CH:10]3[N:14]([C:15](=[O:16])[C:8]=2[C:7]=1[C:27]1[N:32]=[N:31][C:30]([C:33]([OH:35])=O)=[CH:29][CH:28]=1)[CH2:13][CH2:12][CH2:11]3)=[O:5])[CH3:2].[CH2:36]([NH2:42])[C:37]1[O:41][CH:40]=[CH:39][CH:38]=1.Cl.CN(C)CCCN=C=NCC.O.ON1C2C=CC=CC=2N=N1>ClCCl>[F:26][C:23]1[CH:22]=[CH:21][C:20]([CH2:19][C:18]2[C:6]([C:4]([O:3][CH2:1][CH3:2])=[O:5])=[C:7]([C:27]3[N:32]=[N:31][C:30]([C:33]([NH:42][CH2:36][C:37]4[O:41][CH:40]=[CH:39][CH:38]=4)=[O:35])=[CH:29][CH:28]=3)[C:8]3[C:15](=[O:16])[N:14]4[CH:10]([CH2:11][CH2:12][CH2:13]4)[C:9]=3[N:17]=2)=[CH:25][CH:24]=1
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참가 물질

6

반응물 4

HCID 3438FurfurylamineHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 27960291-Hydroxybenzotriazole hydrateHCID 697426146-[3-(Ethoxycarbonyl)-2-(4-fluorobenzyl)-5-oxo-7,8,9,9a-tetrahydro-5h-pyrido[2,3-a]pyrrolizin-4-yl]-3-pyridazinecarboxylic acid

생성물 1

HCID 69743112
Ethyl 2-(4-fluorobenzyl)-4-(6-{[(2-furylmethyl)amino]carbonyl}-3-pyridazinyl)-5-oxo-7,8,9,9a-tetrahydro-5H-pyrido[2,3-alpha]pyrrolizine-3-carboxylate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

The mixture of 6-[3-(ethoxycarbonyl)-2-(4-fluorobenzyl)-5-oxo-7,8,9,9a-tetrahydro-5H-pyrido[2,3-α]pyrrolizin-4-yl]-3-pyridazinecarboxylic acid (G, 33 mg, 0.07 mmol), furfurylamine (19.3 mmol, 0.14 mmol), 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (26.7 mg, 0.14 mmol) and 1-hydroxybenzotriazole hydrate (18.8 mg, 0.14 mmol) in 2 ml dichloromethane was stirred for 2 hours. The mixture was then partitioned between water and ethyl acetate. The organic was washed with brine and dried over sodium sulfate. The residue upon the removal of the solvent was purified with flash chromatography. Twelve (12) mg white solid was obtained. NMR (400 MHz, CDCl3) δ 8.38 (d, 1H), 8.08 (d, 1H), 7.20 (t, 2H), 6.92 (t, 2H), 4.78 (m, 1H), 4.67 (d, 2H), 4.40 (dd, 2H), 3.90 (q, 2H), 3.64 (m, 1H), 3.39 (m, 1H), 2.48 (m, 1H), 2.35 (m, 2H), 1.40 (m, 1H), 0.90 (t, 3H) ppm. ESI-MS m/z 556 (M+H)+.

후처리

  1. customThe mixture was then partitioned between water and ethyl acetate
  2. washThe organic was washed with brine
  3. dry with materialdried over sodium sulfate
  4. customThe residue upon the removal of the solvent
  5. customwas purified with flash chromatography
  6. customwas obtained

출처 및 근거

ORD 기록
ord-1c6202e0957a4f41afaf06bbca2d480f
출처 데이터셋
uspto-grants-2007_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07189851B2

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