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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Allylamine → Ammonium Hydroxide

HRID 458534
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HRID 458534 반응식
[CH:1]1([CH:4]=[O:5])[CH2:3][CH2:2]1.[CH2:6]([NH2:9])[CH:7]=[CH2:8].C([BH3-])#N.[Na+]>CO>[NH4+:9].[OH-:5].[CH:1]1([CH2:4][NH:9][CH2:6][CH:7]=[CH2:8])[CH2:3][CH2:2]1
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참가 물질

6

반응물 3

HCID 7853AllylamineHCID 123114CyclopropanecarboxaldehydeHCID 5003444Sodium cyanoborohydride

생성물 2

HCID 14923Ammonium HydroxideHCID 20460830N-2-Propen-1-ylcyclopropanemethanamine

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Cyclopropanecarboxaldehyde (1.00 g, 14.3 mmol) was added dropwise to a stirred solution of allylamine (4.07 g, 71.3 mmol) in MeOH (100 mL) and stirring was continued at ambient temperature for 2 h, then sodium cyanoborohydride (0.94 g, 15.0 mmol) was added. After 3 h, the solvent was removed under reduced pressure. The crude product was purified by silica gel chromatography, eluting with a gradient of CH2Cl2:MeOH:NH4OH—100:0:0 to 90:10:1 to provide the title compound as a yellow oil. MS: m/z=112 (M+1).

후처리

  1. waitAfter 3 h
  2. customthe solvent was removed under reduced pressure
  3. customThe crude product was purified by silica gel chromatography
  4. washeluting with a gradient of CH2Cl2

출처 및 근거

ORD 기록
ord-36d995fe03094da68f0ee8534ba26c18
출처 데이터셋
uspto-grants-2007_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07192954B2

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