홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

4-(Trifluoromethyl)phenyl isocyanate → 1-(3-{1-(4-methoxybenzyl)-4-[2-(methylamino)pyridin-4-yl]-1H-pyrazol-3-yl}phenyl)-3-[4-(trifluoromethyl)phenyl]urea

HRID 45866
노트
인쇄 미리보기

반응식

HRID 45866 반응식
[NH2:1][C:2]1[CH:3]=[C:4]([C:8]2[C:12]([C:13]3[CH:18]=[CH:17][N:16]=[C:15]([NH:19][CH3:20])[CH:14]=3)=[CH:11][N:10]([CH2:21][C:22]3[CH:27]=[CH:26][C:25]([O:28][CH3:29])=[CH:24][CH:23]=3)[N:9]=2)[CH:5]=[CH:6][CH:7]=1.[F:30][C:31]([F:42])([F:41])[C:32]1[CH:37]=[CH:36][C:35]([N:38]=[C:39]=[O:40])=[CH:34][CH:33]=1.[Na]>CN(C)C=O>[CH3:29][O:28][C:25]1[CH:24]=[CH:23][C:22]([CH2:21][N:10]2[CH:11]=[C:12]([C:13]3[CH:18]=[CH:17][N:16]=[C:15]([NH:19][CH3:20])[CH:14]=3)[C:8]([C:4]3[CH:3]=[C:2]([NH:1][C:39]([NH:38][C:35]4[CH:34]=[CH:33][C:32]([C:31]([F:30])([F:41])[F:42])=[CH:37][CH:36]=4)=[O:40])[CH:7]=[CH:6][CH:5]=3)=[N:9]2)=[CH:27][CH:26]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 737684-(Trifluoromethyl)phenyl isocyanateHCID 5360545SodiumHCID 671862484-[3-(3-aminophenyl)-1-(4-methoxybenzyl)-1H-pyrazol-4-yl]-N-methylpyridin-2-amine

생성물 1

HCID 671843231-(3-{1-(4-methoxybenzyl)-4-[2-(methylamino)pyridin-4-yl]-1H-pyrazol-3-yl}phenyl)-3-[4-(trifluoromethyl)phenyl]urea수율 63%

시약·촉매·용매 1

HCID 6228
Dimethylformamide
용매

실험 절차

250 mg (0.65 mmol) of 4-[3-(3-aminophenyl)-1-(4-methoxybenzyl)-1H-pyrazol-4-yl]-N-methylpyridin-2-amine were dissolved in 10 ml of dry dimethylformamide and 92 μl of p-trifluoromethyl-phenylisocyanate were added. The reaction was stirred at room temperature overnight, poured into aqueous sodium hydrogenocarbonate and extracted with dichloromethane. The organic phase was then dried over sodium sulphate and evaporated. The residue was purified by flash-chromatography on a silica gel column CH2C12-CH3COCH3; from 9/1 to 8/2), giving 234 mg (63%) of the title compound.

후처리

  1. extractionextracted with dichloromethane
  2. dry with materialThe organic phase was then dried over sodium sulphate
  3. customevaporated
  4. customThe residue was purified by flash-chromatography on a silica gel column CH2C12-CH3COCH3

출처 및 근거

ORD 기록
ord-156ace3574a8420d9fecbb93f87a9ee7
출처 데이터셋
uspto-grants-2013_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08541575B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트