Hydrochloric Acid → 5-[(Methoxycarbonyl)amino]pentanoic acid
반응식
Cl.[NH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]([OH:9])=[O:8].C(=O)([O-])[O-].[K+].[K+].Cl[C:17]([O:19][CH2:20]C)=[O:18].Cl>O.O1CCOCC1>[CH3:20][O:19][C:17]([NH:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]([OH:9])=[O:8])=[O:18]참가 물질
7
반응 조건
- 온도
- 0 °C
실험 절차
5-aminopentanoic acid hydrochloride (1 g, 6.5 mmol), and potassium carbonate (6.5 g, 47 mmol) were dissolved in water (15 ml) and dioxane (5 ml) then cooled to 0° C. Ethyl chloroformate (3 ml, 31.5 mmol) was added over 30 seconds, then the mixture was stirred for 4 hours at 0° C. Conc. HCl was added until acidic then the mixture was diluted with water and extracted with ether. The organic layer was dried over magnesium sulfate, evaporated and dried in vacuo to give 5-[(methoxycarbonyl)amino]pentanoic acid as a white powder (1.07 g).
후처리
- extractionextracted with ether
- dry with materialThe organic layer was dried over magnesium sulfate
- customevaporated
- customdried in vacuo
출처 및 근거
- ORD 기록
- ord-5bee31f65f5c435a90e4283a8a234e45
- 출처 데이터셋
- uspto-grants-2007_03
- 특허 번호
- US07192974B2
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