Hydrochloric Acid → 4-[(Methoxycarbonyl)(methyl)amino]butanoic acid

HRID 459049노트

반응식

HRID 459049 반응식
Cl.[CH3:2][NH:3][CH2:4][CH2:5][CH2:6][C:7]([OH:9])=[O:8].C(=O)([O-])[O-].[K+].[K+].Cl[C:17]([O:19][CH3:20])=[O:18].Cl>O.O1CCOCC1>[CH3:20][O:19][C:17]([N:3]([CH3:2])[CH2:4][CH2:5][CH2:6][C:7]([OH:9])=[O:8])=[O:18]

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 6586Methyl chloroformateHCID 11430Potassium CarbonateHCID 126266544-(Methylamino)butyric acid hydrochloride

생성물 1

HCID 184429704-[(Methoxycarbonyl)(methyl)amino]butanoic acid수율 170.4%

시약·촉매·용매 2

HCID 962Water용매2회HCID 312751,4-Dioxane용매

실험 절차

4-(Methylamino)butyric acid hydrochloride (5 g, 32.5 mmol), and potassium carbonate (18 g, 130 mmol) were suspended in water (50 ml) and dioxane (25 ml) then cooled to 0° C. Methyl chloroformate (13 ml, 168 mmol) was added over 1 minute, then the mixture was stirred and allowed to warm slowly to room temperature for 16 hours. Conc. HCl (20 ml) was added then the mixture was diluted with water and extracted with ethyl acetate. The organic layer was dried over magnesium sulfate, evaporated and dried in vacuo to give 4-[(methoxycarbonyl)(methyl)amino]butyric acid as a thick clear oil (9.7 g).

후처리

  1. extractionextracted with ethyl acetate
  2. dry with materialThe organic layer was dried over magnesium sulfate
  3. customevaporated
  4. customdried in vacuo

출처 및 근거

ORD 기록
ord-17349bdd874948b3a3394414256d671c
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07192974B2

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