Hydrochloric Acid → (+/-)-trans-N-[(5-Chloroindol-2-yl)carbonyl]-1,2-cyclohexanediamine hydrochloride

HRID 459473노트

반응식

HRID 459473 반응식
C(O)C.Cl.C(OC([NH:12][C@@H:13]1[CH2:18][CH2:17][CH2:16][CH2:15][C@H:14]1[NH:19][C:20]([C:22]1[NH:23][C:24]2[C:29]([CH:30]=1)=[CH:28][C:27]([Cl:31])=[CH:26][CH:25]=2)=[O:21])=O)(C)(C)C>ClCCl>[ClH:31].[Cl:31][C:27]1[CH:28]=[C:29]2[C:24](=[CH:25][CH:26]=1)[NH:23][C:22]([C:20]([NH:19][C@@H:14]1[CH2:15][CH2:16][CH2:17][CH2:18][C@H:13]1[NH2:12])=[O:21])=[CH:30]2

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 68910309(+/-)-trans-N1-(tert-Butoxycarbonyl)-N2-[(5-chloroindol-2-yl)carbonyl]-1,2-cyclohexanediamine

생성물 1

HCID 18442870(+/-)-trans-N-[(5-Chloroindol-2-yl)carbonyl]-1,2-cyclohexanediamine hydrochloride수율 198.2%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A saturated ethanol solution (100 ml) of hydrochloric acid was added to a solution of (±)-trans-N1-(tert-butoxycarbonyl)-N2-[(5-chloroindol-2-yl)-carbonyl]-1,2-cyclohexanediamine (5.18 g) in dichloromethane (100 ml) at room temperature. After stirring for 2 days, the reaction mixture was concentrated under reduced pressure, diethyl ether (300 ml) was added to the resultant residue, and colorless precipitate formed was collected by filtration and dried to obtain the title compound (4.30 g) as a colorless solid.

후처리

  1. concentrationthe reaction mixture was concentrated under reduced pressure, diethyl ether (300 ml)
  2. additionwas added to the resultant residue, and colorless precipitate
  3. customformed
  4. filtrationwas collected by filtration
  5. customdried

출처 및 근거

ORD 기록
ord-cbf29c6d023345f1ac021a1cdbfe2508
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07192968B2

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