Methyl 7-chloroisoquinoline-3-carboxylate → 7-Chloroisoquinoline-3-carboxylic Acid Hydrochloride
반응식
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[C:7]([C:12]([O:14]C)=[O:13])[N:8]=[CH:9]2)=[CH:4][CH:3]=1>Cl>[ClH:1].[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[C:7]([C:12]([OH:14])=[O:13])[N:8]=[CH:9]2)=[CH:4][CH:3]=1참가 물질
3
실험 절차
Methyl 7-chloroisoquinoline-3-carboxylate (0.23 g) was dissolved in concentrated hydrochloric acid (10 ml) to heat the mixture for 18 hours under reflux. The temperature of the reaction mixture was dropped to room temperature, and deposits were collected by filtration and then washed with water to obtain the title compound (0.21 g) as a colorless solic.
후처리
- temperatureto heat the mixture for 18 hours
- temperatureunder reflux
- additionThe temperature of the reaction mixture was dropped to room temperature
- filtrationdeposits were collected by filtration
- washwashed with water
출처 및 근거
- ORD 기록
- ord-a83256ff3b564142b1366865a4c37194
- 출처 데이터셋
- uspto-grants-2007_03
- 특허 번호
- US07192968B2
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