Potassium Carbonate → HCID 178478161, 화합물

HRID 45965

반응식

HRID 45965 반응식
[Cl:1][C:2]1[CH:18]=[CH:17][C:5]([CH2:6][NH:7][C:8]2[CH:16]=[CH:15][C:11]3[N:12]=[CH:13][NH:14][C:10]=3[CH:9]=2)=[CH:4][CH:3]=1.[N:19]1[S:20][N:21]=[C:22]2[CH:27]=[CH:26][C:25]([CH2:28]Br)=[CH:24][C:23]=12.C([O-])([O-])=O.[K+].[K+]>>[Cl:1][C:2]1[CH:18]=[CH:17][C:5]([CH2:6][N:7]([CH2:28][C:25]2[CH:26]=[CH:27][C:22]3[C:23]([CH:24]=2)=[N:19][S:20][N:21]=3)[C:8]2[CH:16]=[CH:15][C:11]3[NH:12][CH:13]=[N:14][C:10]=3[CH:9]=2)=[CH:4][CH:3]=1

참가 물질

4

반응물 3

HCID 11430Potassium CarbonateHCID 5910045-(Bromomethyl)-2,1,3-benzothiadiazoleHCID 67444221N-(4-Chlorobenzyl)-3H-benzo[d]imidazol-5-amine

생성물 1

HCID 178478161HCID 178478161, 화합물

실험 절차

The compound was synthesized starting from N-(4-chlorobenzyl)benzimidazol-5-amine (258 mg; 1 mmol; 1 eq.), (benzo-[c][1,2,5]-thiadiazol-6-yl)methylbromide (252 mg; 1.1 mmol; 1.1 eq.) and K2CO3 (152 mg; 1.1 mmol; 1.1 eq.) according to method 6; Yield: 0.151 g (37.2%); MS m/z: 406.4/408.3 [M+H]+; 1H-NMR (500 MHz, DMSO d6): δ 4.77 (s, 2H); 4.88 (s, 2H); 6.73-6.79 (m, 2H); 7.32-7.38 (m, 5H); 7.69 (dd, 1H, 4J=1.5 Hz, 3J=9.2 Hz); 7.86 (s, 1H); 7.92 (s, 1H); 8.05 (d, 1H, 3J=9.2 Hz); 11.87 (br s, 1H); HPLC (METHOD [A]): rt 15.88 min (95.9%)

후처리

  1. customThe compound was synthesized
  2. customrt 15.88 min (95.9%)

출처 및 근거

ORD 기록
ord-34b0eb815bfd4cba8af6cb481c4baf2d
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08541596B2

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