Hydrochloric Acid → Ethanamine, 2-(4-iodophenoxy)-N,N-dimethyl-

HRID 459846노트

반응식

[I:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.Cl.[C:10](=O)([O-])[O-].[K+].[K+].[CH3:16][N:17]([CH:19]=O)[CH3:18]>>[I:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:10][CH2:19][N:17]([CH3:18])[CH3:16])=[CH:4][CH:3]=1

참가 물질

반응물 4

HCID 313Hydrochloric Acid

HCID 6228Dimethylformamide

HCID 108944-Iodophenol

HCID 11430Potassium Carbonate

생성물 1

HCID 887465Ethanamine, 2-(4-iodophenoxy)-N,N-dimethyl-

실험 절차

4-Iodophenol was reacted with 2-chlorodimethylamioethane hydrochloride in DMF under heating in the presence of potassium carbonate to obtain [2-(4-iodophenoxy)ethyl]dimethylamine. The obtained compound was reacted in toluene under heating in the presence of t-butyl piperazine-1-carboxylate, sodium t-butoxide, tri(2-methylphenyl)phosphine and a catalytic amount of tris(dibenzylideneacetone)dipalladium(0) to obtain an objective compound.

출처 및 근거

ORD 기록: ord-36a9c035af704ab289404b4aaa6d15a8
출처 데이터셋: uspto-grants-2007_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07196080B2

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